March 1, 2026
Profhilo is one of the most popular beauty treatments nowadays since it promises to promote radiance and skin hydration in addition to correcting wrinkled skin that becomes saggy with aging. This treatment helps to increase collagen and elastin production in your sin using injectable hyaluronic acid.

Simulated demonstration of Profhilo's bio-remodelling effect on skin quality. The change is hydration and texture rather than volume — skin looks tighter, bouncier and more luminous without any contour change.
Profhilo is a non-surgical skin remodeling treatment. It contains a very high concentration of hyaluronic acid that is designed for people who lost their skin volume and elasticity, especially with aging. (1) It is not only about plumping and filling aging signs like wrinkles and fine lines, but also about stimulating the skin to produce collagen and elastin by the slow-releasing process of hyaluronic acid in the skin. Stimulating collagen and elastin production improves skin tone, increases hydration of the skin, and reduces the appearance of fine lines and wrinkles. In conclusion, the quality of the skin improves significantly for the next 6 months after treatment.
Hyaluronic acid is a hydrophilic substance, which means that it draws and retains water from the body. In other words, Hyaluronic acid works as a hydration agent, not a filler, which is great for people with saggy, tired, dull-looking skin that is full of wrinkles and aging signs. After 3 to 5 days of treatment, the skin will be firm and luminous. (2) Over the next few weeks of treatment, collagen and elastin production will be stimulated, which makes the skin tighter. The main concept here is that the levels of collagen and Hyaluronic Acid starts to decrease rapidly after the age of 30, which is why the aging signs such as fine lines and wrinkles start to develop after 30. Profhilo simply works by reversing some of these aging changes. The optimal results are usually seen after the second treatment. (3)
Profhilo has many benefits for the skin including (4):

Profhilo's standard protocol — two sessions one month apart — lasts 6-9 months. Other HA bio-stimulator regimens have similar timelines; standard structural fillers last longer but treat a different concern.
Profhilo is usually injected over 2 sessions with 4 weeks between them below the surface of the skin. After the injection procedure, it starts dispersing under the skin’s surface to promote hydration. You do not have to massage the treated areas since there is no risk of developing lumps or nodules. Profhilo injection works within a 2km radius of the site of injection. Therefore, it only requires 10 injections sites to cover the entire face. After completing the Profhilo course and getting the 2 injections, intense hydration and enhancement of collagen production are expected. Your skin will glow, fine lines and wrinkles will start disappearing over time, and the treated areas will be smoother and firmer. After 6 months, you may need to get another treatment course to maintain the results.

Profhilo targets skin quality — hydration, bounce, fine crepey texture — not volume restoration. For real volume loss, structural fillers; for significant laxity, radiofrequency or ultrasound tightening.
After the treatment, the recovery time is minimal. You will be able to get back to your daily routine immediately after the procedure. However, you should do light activities for the first few days after the procedure. It is recommended to avoid any physical strain or sports activities on the first day. Besides, sauna and steamy baths should be avoided for several days in addition to extreme sunlight or Ultraviolet exposure. (5)
All non-surgical aesthetic treatments have side effects, including Profhilo. However, they are minimal and do not remain for a long time. Minimal bruising, swelling, and redness at the injection sites are expected. In most cases, they do not occur and usually disappear quickly after the procedure. Keep in mind that Profhilo is not recommended for pregnant or breastfeeding women in addition to women who are sensitive or allergic to Hyaluronic acid. (6)
The most common price for a single Profhilo session is £250. Of course, this price varies depending on where you live and how bad the condition is. Keep in mind that you need at least two treatments a month apart. Therefore, you should double the price of a single session.
Profhilo is sometimes referred to as a 3D biomodelling treatment since its effects are not only on your appearance but also on how the body regenerates new cells and renews itself. In short, Profhilo is one of the best treatments that enable our bodies to do their jobs better than they actually do. It is a highly recommended treatment for people who want to experience transformative effects on their skin appearance and overall health.
Profhilo is recommended for people over 30 who do not feel comfortable with the laxity of their skin or any visible aging signs such as fine lines and wrinkles.
Profhilo depends on injecting the substances under the skin at certain points using fine needles. On the face, 5 injection sites will be determined on each side to provide you with the maximum results. The procedure is painless and, in most cases, there is no need to use a topical pain relief cream after it. Also, it is quick and does not take more than 10 minutes. Therefore, you can get back to your routine immediately after the procedure.
Patients who suffer from bleeding disorders or have compromised immune systems such as cancer patients, diabetic patients, or people who have HIV or any infectious diseases should talk to their doctor before considering Profhilo. Besides, pregnant or breastfeeding women should avoid cosmetic injectable treatments. It is also necessary to find a high-qualified doctor to do the procedure. (7)
Sparavigna A, Tenconi B. Efficacy and tolerance of an injectable medical device containing stable hybrid cooperative complexes of high- and low-molecular-weight hyaluronic acid: a monocentric 16 weeks open-label evaluation. Clin Cosmet Investig Dermatol. 2016;9:297-305. Published 2016 Sep 26. doi:10.2147/CCID.S114450
Stellavato A, Corsuto L, D'Agostino A, La Gatta A, Diana P, Bernini P, De Rosa M, Schiraldi C. Hyaluronan Hybrid Cooperative Complexes as a Novel Frontier for Cellular Bioprocesses Re-Activation. PLoS One. 2016 Oct 10;11(10):e0163510. doi: 10.1371/journal.pone.0163510. PMID: 27723763; PMCID: PMC5056743.