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What Is Profhilo?

Facial Procedures

March 1, 2026

AUTHOR
Sony Sherpa
MD, Manipal College of Medical Sciences

    Profhilo is one of those treatments you have probably seen everywhere lately. The pitch is simple: more radiance, more hydration, and smoother skin that has started to sag a little with age.

    It does this with injectable hyaluronic acid that nudges your skin into making more of its own collagen and elastin.

    Crepey skin and mild laxity before and after Profhilo bio-remodelling treatment
    Figure 1

    Simulated demonstration of Profhilo's bio-remodelling effect on skin quality. The change is hydration and texture rather than volume — skin looks tighter, bouncier and more luminous without any contour change.

    What is Profhilo?

    Profhilo is a non-surgical skin remodeling treatment. It uses a very high concentration of hyaluronic acid and is meant for people who have lost some skin volume and elasticity, usually with age (1).

    It is not just about plumping and filling lines and wrinkles. The hyaluronic acid releases slowly into the skin, which nudges it to produce more collagen and elastin on its own. That improves skin tone, boosts hydration, and softens fine lines and wrinkles.

    The improvement holds for about 6 months after treatment.

    How does Profhilo work?

    Hyaluronic acid is hydrophilic, which is a fancy way of saying it pulls in and holds water from the body. So it works more like a hydration agent than a filler, which is exactly what you want if your skin looks tired, dull, and lined. Within 3 to 5 days of treatment, the skin starts to feel firmer and look more luminous (2).

    Over the following weeks, the treatment stimulates collagen and elastin, which tightens the skin. The reason this matters is that collagen and hyaluronic acid levels start dropping fast after the age of 30, which is roughly when fine lines and wrinkles begin to set in. Profhilo works by reversing some of that. You usually see the best results after the second treatment (3).

    What are the benefits of Profhilo?

    Profhilo does a lot for the skin (4):

    • Tightens loose, lax skin.
    • Makes the skin feel firmer.
    • Restores lost volume, which helps with sagging and sunken-looking eyes.
    • Smooths fine lines and wrinkles.
    • Prompts the skin to make more of its own collagen and elastin.
    • Deeply hydrates the skin.
    • Helps head off future volume loss and dullness.
    • Brings back some radiance.
    • Works on more than the face, including the neck, chest, arms, knees, and hands.
    Profhilo and related bio-remodelling treatments, duration of effect in months
    Figure 2

    Profhilo's standard protocol — two sessions one month apart — lasts 6-9 months. Other HA bio-stimulator regimens have similar timelines; standard structural fillers last longer but treat a different concern.

    What does Profhilo treatment involve?

    Profhilo is usually given over 2 sessions, 4 weeks apart, just below the surface of the skin. Once injected, it spreads under the skin to boost hydration. You do not need to massage the treated areas, since there is no real risk of lumps or nodules forming.

    Each injection works within about a 2cm radius, so it only takes 10 injection sites to cover the whole face.

    After both sessions, you can expect deep hydration and a real bump in collagen production. Your skin glows, fine lines and wrinkles fade over time, and the treated areas feel smoother and firmer. After about 6 months, you may want another course to keep the results going.

    Decision tree for Profhilo candidacy by skin concern and severity
    Figure 3

    Profhilo targets skin quality — hydration, bounce, fine crepey texture — not volume restoration. For real volume loss, structural fillers; for significant laxity, radiofrequency or ultrasound tightening.

    What about Profhilo recovery?

    Recovery is minimal. You can get back to your day right after the procedure, though it is smart to keep things light for the first few days. Avoid any physical strain or sport on the first day. You should also skip saunas and steamy baths for several days, along with strong sun or UV exposure (5).

    What are the side effects of Profhilo?

    Like any non-surgical aesthetic treatment, Profhilo has side effects, but they are mild and short-lived. You might see a little bruising, swelling, or redness at the injection sites. Often none of that shows up at all, and when it does, it usually clears quickly.

    One thing to keep in mind: Profhilo is not recommended for pregnant or breastfeeding women, or for anyone who is sensitive or allergic to hyaluronic acid (6).

    How much does Profhilo cost?

    A single Profhilo session usually costs around £250. That number shifts depending on where you live and how much work your skin needs. Remember that you need at least two treatments a month apart, so it is fair to double that single-session price when you budget for it.

    FAQ about Profhilo

    What is a 3D biomodelling treatment?

    Profhilo is sometimes called a 3D biomodelling treatment, because its effects are not only on how you look but on how your body renews and regenerates its own cells.

    In short, it helps your skin renew itself a little better than it would on its own, which is why it appeals to people who want more than a surface fix.

    Who is Profhilo suitable for?

    Profhilo is aimed at people over 30 who are not happy with their skin laxity or with visible signs of aging like fine lines and wrinkles.

    What is Profhilo like?

    Profhilo is injected just under the skin at specific points using fine needles. On the face, that means 5 injection sites on each side for the best result.

    The procedure is painless, and most people do not even need a numbing cream afterward.

    It is also quick, usually under 10 minutes, so you can head back to your routine straight away.

    What are the contraindications of Profhilo?

    Anyone with a bleeding disorder or a compromised immune system, including people with cancer, diabetes, HIV, or other infectious diseases, should talk to their doctor before considering Profhilo.

    Pregnant or breastfeeding women should avoid cosmetic injectable treatments altogether.

    It is also worth finding a highly qualified doctor to do the procedure (7).

    References

    1. 1

      Cassuto D, Delledonne M, Zaccaria G, Illiano I, Giori AM, Bellia G. Safety Assessment of High- and Low-Molecular-Weight Hyaluronans (Profhilo®) as Derived from Worldwide Postmarketing Data. Biomed Res Int. 2020;2020:8159047. Published 2020 Jun 20. doi:10.1155/2020/8159047

    2. 2

      Sparavigna A, Tenconi B. Efficacy and tolerance of an injectable medical device containing stable hybrid cooperative complexes of high- and low-molecular-weight hyaluronic acid: a monocentric 16 weeks open-label evaluation. Clin Cosmet Investig Dermatol. 2016;9:297-305. Published 2016 Sep 26. doi:10.2147/CCID.S114450

    3. 3

      Cassuto D, Delledonne M, Zaccaria G, Illiano I, Giori AM, Bellia G. Safety Assessment of High- and Low-Molecular-Weight Hyaluronans (Profhilo®) as Derived from Worldwide Postmarketing Data. Biomed Res Int. 2020 Jun 20;2020:8159047. doi: 10.1155/2020/8159047. PMID: 32685528; PMCID: PMC7327616.

    4. 4

      Laurino C, Palmieri B, Coacci A. Efficacy, Safety, and Tolerance of a New Injection Technique for High- and Low-Molecular-Weight Hyaluronic Acid Hybrid Complexes. Eplasty. 2015;15:e46. Published 2015 Oct 8.

    5. 5

      Stellavato A, Corsuto L, D'Agostino A, La Gatta A, Diana P, Bernini P, De Rosa M, Schiraldi C. Hyaluronan Hybrid Cooperative Complexes as a Novel Frontier for Cellular Bioprocesses Re-Activation. PLoS One. 2016 Oct 10;11(10):e0163510. doi: 10.1371/journal.pone.0163510. PMID: 27723763; PMCID: PMC5056743.

    6. 6

      King M. The Management of Bruising following Nonsurgical Cosmetic Treatment. J Clin Aesthet Dermatol. 2017;10(2):E1-E4.

    7. 7

      Homsy A, Rüegg EM, Jandus P, Pittet-Cuénod B, Modarressi A. Immunological reaction after facial hyaluronic acid injection. Case Reports Plast Surg Hand Surg. 2017;4(1):68-72. Published 2017 Jul 19. doi:10.1080/23320885.2017.1356202